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mining-molecular-data-with-cryogenic-electron-microscopy-unveils-hidden-biological-secrets
mining-molecular-data-with-cryogenic-electron-microscopy-unveils-hidden-biological-secrets

Mining molecular data with cryogenic electron microscopy unveils hidden biological secrets

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A groundbreaking technique known as cryogenic electron microscopy or cryo-EM has been used by Arizona State University researchers in a new approach to studying molecules of life.

Examining not only their static structures at high resolution but the all-important dynamic movements of such molecules as they carry out biological functions, molecules targeted for study are flash-frozen in a thin membrane of ice before being subjected to electron microscopy.

Tens or even hundreds of thousands of still images are collected, then reassembled by means of computer.

The technique offers a powerful alternative to X-ray crystallography for probing the molecular world in keen detail.

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